Visceral Leishmaniasis Revealing Undiagnosed Inborn Errors of Immunity

Abstract

ABSTRACT Visceral Leishmaniasis (VL) is a potentially fatal disease and may be associated with primary or acquired immunodeficiencies. There are few reports, in the literature, of inborn errors of immunity. Here, we report two cases of VL as a marker of inborn errors of immunity, namely, GATA2 and RAB27A deficiency. Our data suggest that VL patients should be screened for primary immunodeficiency, particularly in cases of VL relapse.

Keywords

• Visceral Leishmaniasis
• Primary Immunodeficiency
• Cellular immunodeficiency