Nature Communications (Mar 2016)

Direct evidence for sequence-dependent attraction between double-stranded DNA controlled by methylation

  • Jejoong Yoo,
  • Hajin Kim,
  • Aleksei Aksimentiev,
  • Taekjip Ha

DOI
https://doi.org/10.1038/ncomms11045
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 7

Abstract

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Theoretical studies suggest that homologous DNA duplexes can preferentially associate with one another in the absence of proteins. Here, the authors show that GC-rich DNA with methylated cytosine and AT-rich DNA duplexes associate more strongly than GC-rich duplexes regardless of the sequence homology.