Nature Communications (Jan 2021)
Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
- Garan Jones,
- Katerina Trajanoska,
- Adam J. Santanasto,
- Najada Stringa,
- Chia-Ling Kuo,
- Janice L. Atkins,
- Joshua R. Lewis,
- ThuyVy Duong,
- Shengjun Hong,
- Mary L. Biggs,
- Jian’an Luan,
- Chloe Sarnowski,
- Kathryn L. Lunetta,
- Toshiko Tanaka,
- Mary K. Wojczynski,
- Ryan Cvejkus,
- Maria Nethander,
- Sahar Ghasemi,
- Jingyun Yang,
- M. Carola Zillikens,
- Stefan Walter,
- Kamil Sicinski,
- Erika Kague,
- Cheryl L. Ackert-Bicknell,
- Dan E. Arking,
- B. Gwen Windham,
- Eric Boerwinkle,
- Megan L. Grove,
- Misa Graff,
- Dominik Spira,
- Ilja Demuth,
- Nathalie van der Velde,
- Lisette C. P. G. M. de Groot,
- Bruce M. Psaty,
- Michelle C. Odden,
- Alison E. Fohner,
- Claudia Langenberg,
- Nicholas J. Wareham,
- Stefania Bandinelli,
- Natasja M. van Schoor,
- Martijn Huisman,
- Qihua Tan,
- Joseph Zmuda,
- Dan Mellström,
- Magnus Karlsson,
- David A. Bennett,
- Aron S. Buchman,
- Philip L. De Jager,
- Andre G. Uitterlinden,
- Uwe Völker,
- Thomas Kocher,
- Alexander Teumer,
- Leocadio Rodriguéz-Mañas,
- Francisco J. García,
- José A. Carnicero,
- Pamela Herd,
- Lars Bertram,
- Claes Ohlsson,
- Joanne M. Murabito,
- David Melzer,
- George A. Kuchel,
- Luigi Ferrucci,
- David Karasik,
- Fernando Rivadeneira,
- Douglas P. Kiel,
- Luke C. Pilling
Affiliations
- Garan Jones
- Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School
- Katerina Trajanoska
- Department of Internal Medicine, Erasmus Medical Center
- Adam J. Santanasto
- University of Pittsburgh, Department of Epidemiology
- Najada Stringa
- Department of Epidemiology and Biostatistics, Amsterdam UMC- Vrije Universiteit, Amsterdam Public Health Research Institute
- Chia-Ling Kuo
- Biostatistics Center, Connecticut Convergence Institute for Translation in Regenerative Engineering, UConn Health
- Janice L. Atkins
- Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School
- Joshua R. Lewis
- School of Medical and Health Sciences, Edith Cowan University
- ThuyVy Duong
- McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine
- Shengjun Hong
- Lübeck Interdisciplinary Plattform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck
- Mary L. Biggs
- Cardiovascular Health Research Unit, Department of Medicine, and Department of Biostatistics, University of Washington
- Jian’an Luan
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine
- Chloe Sarnowski
- Biostatistics Department, Boston University School of Public Health
- Kathryn L. Lunetta
- Biostatistics Department, Boston University School of Public Health
- Toshiko Tanaka
- Longitudinal Study Section, Translational Gerontology branch, National Institute on Aging
- Mary K. Wojczynski
- Department of Genetics, Washington University School of Medicine
- Ryan Cvejkus
- University of Pittsburgh, Department of Epidemiology
- Maria Nethander
- Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Sahar Ghasemi
- Department of Psychiatry and Psychotherapy, University Medicine Greifswald
- Jingyun Yang
- Rush Alzheimer’s Disease Center & Department of Neurological Sciences, Rush University Medical Center
- M. Carola Zillikens
- Department of Internal Medicine, Erasmus Medical Center
- Stefan Walter
- Department of Medicine and Public Health, Rey Juan Carlos University
- Kamil Sicinski
- Center for Demography of Health and Aging, University of Wisconsin-Madison
- Erika Kague
- School of Physiology, Pharmacology and Neuroscience, University of Bristol
- Cheryl L. Ackert-Bicknell
- Department of Orthopedics, University of Colorado
- Dan E. Arking
- McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine
- B. Gwen Windham
- Department of Medicine/Geriatrics, University of Mississippi School of Medicine
- Eric Boerwinkle
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Megan L. Grove
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Misa Graff
- Department of Epidemiology, University of North Carolina
- Dominik Spira
- Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Ilja Demuth
- Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
- Nathalie van der Velde
- Department of Internal Medicine, Section of Geriatric Medicine, Academic Medical Center, University of Amsterdam
- Lisette C. P. G. M. de Groot
- Wageningen University, Division of Human Nutrition
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health services, University of Washington
- Michelle C. Odden
- Department of Epidemiology and Population Health, Stanford University
- Alison E. Fohner
- Department of Epidemiology and Institute of Public Genetics, University of Washington
- Claudia Langenberg
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine
- Nicholas J. Wareham
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine
- Stefania Bandinelli
- Geriatric Unit, Azienda Sanitaria Firenze (ASF)
- Natasja M. van Schoor
- Department of Epidemiology and Biostatistics, Amsterdam UMC- Vrije Universiteit, Amsterdam Public Health Research Institute
- Martijn Huisman
- Department of Epidemiology and Biostatistics, Amsterdam UMC- Vrije Universiteit, Amsterdam Public Health Research Institute
- Qihua Tan
- Epidemiology and Biostatistics, Department of Public Health, Faculty of Health Science, University of Southern Denmark
- Joseph Zmuda
- University of Pittsburgh, Department of Epidemiology
- Dan Mellström
- Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Magnus Karlsson
- Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Lund University, Skåne University Hospital
- David A. Bennett
- Rush Alzheimer’s Disease Center & Department of Neurological Sciences, Rush University Medical Center
- Aron S. Buchman
- Rush Alzheimer’s Disease Center & Department of Neurological Sciences, Rush University Medical Center
- Philip L. De Jager
- Center for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center
- Andre G. Uitterlinden
- Department of Internal Medicine, Erasmus Medical Center
- Uwe Völker
- Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
- Thomas Kocher
- Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald
- Alexander Teumer
- Institute for Community Medicine, University Medicine Greifswald
- Leocadio Rodriguéz-Mañas
- CIBER of Frailty and Healthy Aging (CIBERFES)
- Francisco J. García
- CIBER of Frailty and Healthy Aging (CIBERFES)
- José A. Carnicero
- CIBER of Frailty and Healthy Aging (CIBERFES)
- Pamela Herd
- Professor of Public Policy, Georgetown University
- Lars Bertram
- Lübeck Interdisciplinary Plattform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck
- Claes Ohlsson
- Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Joanne M. Murabito
- Section of General Internal Medicine, Boston University School of Medicine
- David Melzer
- Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School
- George A. Kuchel
- Center on Aging, University of Connecticut Health
- Luigi Ferrucci
- National Institute on Aging
- David Karasik
- Marcus Institute for Aging Research, Hebrew SeniorLife
- Fernando Rivadeneira
- Department of Internal Medicine, Erasmus Medical Center
- Douglas P. Kiel
- Marcus Institute for Aging Research, Hebrew SeniorLife and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Broad Institute of MIT & Harvard
- Luke C. Pilling
- Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School
- DOI
- https://doi.org/10.1038/s41467-021-20918-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Muscle weakness has been associated with morbidity and mortality in older people. Here, the authors have investigated this trait further by performing a genome-wide meta-analysis of grip strength and Mendelian randomization to discover causal relationships between muscle weakness and other diseases.
