PECULIARITIES OF RECOMBINATIVE GENOMICS OF ACINETOBACTER — HUMAN PATHOGEN

Abstract

Aim. The disclosure of the role of genetic markers variability among Acinetobacter genus in connection with multidrug-resistant phenotype realization. Materials and methods. A comparative analysis was reviewed on DNA fragments important for genetic recombination in A. baumannii — one of the most relevant pathogens of postoperative infection, as well as A. pittii and A. lwoffii. Results. Integrase/recombinase XerC gene-bearing region of the chromosome is notably different and could include the genes responsible for the development of resistance against polymyxins and (fluoro)quinolones, as well as other antibiotics. Conclusion. The results obtained are important in surveillance of epidemic (pandemic) strains of Acinetobacter spp.

Keywords

• acinetobacter baumannii
• epidemic (pandemic) clone
• antibiotic resistance
• multidrug efflux transporters
• integrase/recombinase xerc