BIOACTIVE POTENCY OF RED ALGAE (Gracillaria verrucosa) EXTRACT TOWARDS MALONDIALDEHYDE LEVEL AND LUNG HISTOLOGY OF WHITE RAT (Rattus novergicus) AFTER FORMALIN INDUCTION

Abstract

Indonesia is a megabiodiversity state that has many natural sources. Red algae (Glacillaria verrucosa) as one of the natural sources, contains antioxidant compounds. The aim of this study was to determine the bioactive potency of red algae extract for white rat (Rattus novergicus) therapy, based on malondialdehyde (MDA) level and lung histology. The method consists of red algae extraction and characterization, induction of animal model with formalin and therapy with variation dosage. Based on phytochemistry test, FTIR and LCMS analysis, red algae extract contains flavonoid, terpenoid, alkaloid, β-carotene, β-apo-8’-carotenal, and α-tocopherol as antioxidant. Formalin can increase level of MDA and defect the bronchus ephitelium cell than the normal condition. Appropriate dosage can decrease the MDA level and repair the bronchus ephitelium cell. The optimum dosage is 100 mg/kg body weight.

Keywords

• red algae extract
• MDA level
• lung histology
• formalin induction