Communications Biology (Dec 2021)

Rats exhibit age-related mosaic loss of chromosome Y

  • Alberto H. Orta,
  • Stephen J. Bush,
  • Mariana Gutiérrez-Mariscal,
  • Susana Castro-Obregón,
  • Lorraine Jaimes-Hoy,
  • Ricardo Grande,
  • Gloria Vázquez,
  • Elisa Gorostieta-Salas,
  • Mónica Martínez-Pacheco,
  • Karina Díaz-Barba,
  • Paola Cornejo-Páramo,
  • Alejandro Sanchez-Flores,
  • Tamas Székely,
  • Araxi O. Urrutia,
  • Diego Cortez

DOI
https://doi.org/10.1038/s42003-021-02936-y
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 8

Abstract

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Alberto Orta et al. demonstrate that frequent mosaic loss of chromosome Y (LOY) observed in aging men might also be present in rats. They show that, like in humans, LOY in rats is associated with aging, but is not dependent on environmental stressors, and may be a natural process in placental mammals.