Frontiers in Oncology (Jul 2020)
VCAM1 Promotes Tumor Cell Invasion and Metastasis by Inducing EMT and Transendothelial Migration in Colorectal Cancer
- Dan Zhang,
- Dan Zhang,
- Jiaxin Bi,
- Jiaxin Bi,
- Qiaoyan Liang,
- Qiaoyan Liang,
- Shuyang Wang,
- Shuyang Wang,
- Lingjie Zhang,
- Lingjie Zhang,
- Fangyi Han,
- Fangyi Han,
- Shengnan Li,
- Shengnan Li,
- Bowen Qiu,
- Bowen Qiu,
- Xingdi Fan,
- Xingdi Fan,
- Wei Chen,
- Wei Chen,
- Hongli Jiao,
- Hongli Jiao,
- Yaping Ye,
- Yaping Ye,
- Yanqing Ding,
- Yanqing Ding
Affiliations
- Dan Zhang
- Department of Pathology, School of Basic Medical Sciences and Nanfang Hospital, Southern Medical University, Guangzhou, China
- Dan Zhang
- Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China
- Jiaxin Bi
- Department of Pathology, School of Basic Medical Sciences and Nanfang Hospital, Southern Medical University, Guangzhou, China
- Jiaxin Bi
- Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China
- Qiaoyan Liang
- Department of Pathology, School of Basic Medical Sciences and Nanfang Hospital, Southern Medical University, Guangzhou, China
- Qiaoyan Liang
- Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China
- Shuyang Wang
- Department of Pathology, School of Basic Medical Sciences and Nanfang Hospital, Southern Medical University, Guangzhou, China
- Shuyang Wang
- Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China
- Lingjie Zhang
- Department of Pathology, School of Basic Medical Sciences and Nanfang Hospital, Southern Medical University, Guangzhou, China
- Lingjie Zhang
- Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China
- Fangyi Han
- Department of Pathology, School of Basic Medical Sciences and Nanfang Hospital, Southern Medical University, Guangzhou, China
- Fangyi Han
- Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China
- Shengnan Li
- Department of Pathology, School of Basic Medical Sciences and Nanfang Hospital, Southern Medical University, Guangzhou, China
- Shengnan Li
- Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China
- Bowen Qiu
- Department of Pathology, School of Basic Medical Sciences and Nanfang Hospital, Southern Medical University, Guangzhou, China
- Bowen Qiu
- Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China
- Xingdi Fan
- Department of Pathology, School of Basic Medical Sciences and Nanfang Hospital, Southern Medical University, Guangzhou, China
- Xingdi Fan
- Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China
- Wei Chen
- Department of Pathology, School of Basic Medical Sciences and Nanfang Hospital, Southern Medical University, Guangzhou, China
- Wei Chen
- Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China
- Hongli Jiao
- Department of Pathology, School of Basic Medical Sciences and Nanfang Hospital, Southern Medical University, Guangzhou, China
- Hongli Jiao
- Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China
- Yaping Ye
- Department of Pathology, School of Basic Medical Sciences and Nanfang Hospital, Southern Medical University, Guangzhou, China
- Yaping Ye
- Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China
- Yanqing Ding
- Department of Pathology, School of Basic Medical Sciences and Nanfang Hospital, Southern Medical University, Guangzhou, China
- Yanqing Ding
- Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Guangzhou, China
- DOI
- https://doi.org/10.3389/fonc.2020.01066
- Journal volume & issue
-
Vol. 10
Abstract
Vascular cell adhesion molecular 1 (VCAM1), an important member of the immunoglobulin superfamily, is related to the development of malignant tumors, such as breast cancer, melanoma, and renal clear cell carcinoma. However, the molecular role and mechanism of VCAM1 in the regulation of the progression of colorectal cancer (CRC) has rarely been studied. The results of IHC and RT-PCR analyses proved that VCAM1 was upregulated in human CRC tissues compared with matched adjacent normal intestinal epithelial tissues. Moreover, analysis of data from the TCGA and Gene Expression Omnibus (GEO) databases revealed that a higher level of VCAM1 was strongly correlated with poor differentiation, metastasis, and short survival in CRC patients. Furthermore, VCAM1 significantly influenced the invasion and metastasis of CRC cells in vitro and in vivo and activated the EMT program, by which cancer cells adhere to the endothelium and cross the vessel wall by forming pseudopodia and invadopodia. The current findings demonstrate that VCAM1 promotes tumor progression in CRC.
Keywords
