DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions

Markus Sauer; Stefan A. Juranek; James Marks; Alessio De Magis; Hinke G. Kazemier; Daniel Hilbig; Daniel Benhalevy; Xiantao Wang; Markus Hafner; Katrin Paeschke

doi:10.1038/s41467-019-10432-5

Nature Communications (Jun 2019)

DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions

Markus Sauer,
Stefan A. Juranek,
James Marks,
Alessio De Magis,
Hinke G. Kazemier,
Daniel Hilbig,
Daniel Benhalevy,
Xiantao Wang,
Markus Hafner,
Katrin Paeschke

Affiliations

Markus Sauer: Department of Biochemistry, Biocenter, University of Würzburg
Stefan A. Juranek: Department of Oncology, Hematology and Rheumatology, University Hospital Bonn
James Marks: Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH
Alessio De Magis: Department of Oncology, Hematology and Rheumatology, University Hospital Bonn
Hinke G. Kazemier: European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of Groningen
Daniel Hilbig: Department of Oncology, Hematology and Rheumatology, University Hospital Bonn
Daniel Benhalevy: Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH
Xiantao Wang: Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH
Markus Hafner: Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH
Katrin Paeschke: Department of Biochemistry, Biocenter, University of Würzburg

DOI: https://doi.org/10.1038/s41467-019-10432-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Translation efficiency can be affected by mRNA stability and secondary RNA structures. Here the authors reveal that loss of DHX36 helicase activity leads to an accumulation of translationally inactive target mRNAs with G-rich structures in untranslated regions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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