A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population

Wendi Zhang; Yang Hu; Min Qian; Liping Mao; Yanqiong Yuan; Huiwen Xu; Yiran Liu; Anni Qiu; Yan Zhou; Yang Dong; Yutong Wu; Qiong Chen; Xiaobo Tao; Tian Tian; Lei Zhang; Jiahua Cui; Minjie Chu

iScience (Nov 2023)

A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population

Wendi Zhang,
Yang Hu,
Min Qian,
Liping Mao,
Yanqiong Yuan,
Huiwen Xu,
Yiran Liu,
Anni Qiu,
Yan Zhou,
Yang Dong,
Yutong Wu,
Qiong Chen,
Xiaobo Tao,
Tian Tian,
Lei Zhang,
Jiahua Cui,
Minjie Chu

Affiliations

Wendi Zhang: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China
Yang Hu: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China
Min Qian: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China
Liping Mao: Department of Oncology, Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), Nantong, Jiangsu, China
Yanqiong Yuan: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China
Huiwen Xu: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China
Yiran Liu: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China
Anni Qiu: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China
Yan Zhou: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China
Yang Dong: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China
Yutong Wu: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China
Qiong Chen: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China
Xiaobo Tao: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China
Tian Tian: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China
Lei Zhang: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China; Corresponding author
Jiahua Cui: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China; Corresponding author
Minjie Chu: Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China; Corresponding author

Journal volume & issue: Vol. 26, no. 11
p. 108068

Abstract

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Summary: The role of alternative polyadenylation (APA) in tumor development is becoming increasingly evident, but the impact of APA events on the prognosis of LUAD patients is unclear. Therefore, in the present study, we aimed to analyze specific APA events in LUAD to identify novel prognostic biomarkers for LUAD. We first identified prognostic candidate genes for LUAD associated with APA events and validated them in both the East Asian and the USA cohorts, finding that five genes (DCUN1D5, PSMC4, TFAM, THRA, and TMEM100) were of prognostic significance in both populations. Based on this, an APA-based prognostic signature was constructed for the East Asian population. The predictive accuracy of the prognostic signature was further evaluated by the time-dependent ROC, with 1-, 2-, and 3-year AUCs of 0.86, 0.81, and 0.71, respectively. This study may provide new markers for individualized diagnosis and prognostic assessment of LUAD and potential targets for precision treatment.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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