Nature Communications (Dec 2019)

PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome

  • Deepti Sharma,
  • Louis De Falco,
  • Sivaraman Padavattan,
  • Chang Rao,
  • Susana Geifman-Shochat,
  • Chuan-Fa Liu,
  • Curt A. Davey

DOI
https://doi.org/10.1038/s41467-019-13641-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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The poly(ADP-ribose) polymerases play a key role in maintaining genomic integrity by detecting DNA damage and mediating repair. Here the authors characterize the kinetics of PARP1 binding to a variety of nucleosomes harbouring DNA double-strand breaks.