Nature Communications (Oct 2021)
Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity
- Anukul T. Shenoy,
- Carolina Lyon De Ana,
- Emad I. Arafa,
- Isabelle Salwig,
- Kimberly A. Barker,
- Filiz T. Korkmaz,
- Aditya Ramanujan,
- Neelou S. Etesami,
- Alicia M. Soucy,
- Ian M. C. Martin,
- Brian R. Tilton,
- Anne Hinds,
- Wesley N. Goltry,
- Hasmeena Kathuria,
- Thomas Braun,
- Matthew R. Jones,
- Lee J. Quinton,
- Anna C. Belkina,
- Joseph P. Mizgerd
Affiliations
- Anukul T. Shenoy
- Pulmonary Center, Boston University School of Medicine
- Carolina Lyon De Ana
- Pulmonary Center, Boston University School of Medicine
- Emad I. Arafa
- Pulmonary Center, Boston University School of Medicine
- Isabelle Salwig
- Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL)
- Kimberly A. Barker
- Pulmonary Center, Boston University School of Medicine
- Filiz T. Korkmaz
- Pulmonary Center, Boston University School of Medicine
- Aditya Ramanujan
- Pulmonary Center, Boston University School of Medicine
- Neelou S. Etesami
- Pulmonary Center, Boston University School of Medicine
- Alicia M. Soucy
- Pulmonary Center, Boston University School of Medicine
- Ian M. C. Martin
- Pulmonary Center, Boston University School of Medicine
- Brian R. Tilton
- Flow Cytometry Core Facility, Boston University School of Medicine
- Anne Hinds
- Pulmonary Center, Boston University School of Medicine
- Wesley N. Goltry
- Pulmonary Center, Boston University School of Medicine
- Hasmeena Kathuria
- Pulmonary Center, Boston University School of Medicine
- Thomas Braun
- Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL)
- Matthew R. Jones
- Pulmonary Center, Boston University School of Medicine
- Lee J. Quinton
- Pulmonary Center, Boston University School of Medicine
- Anna C. Belkina
- Pulmonary Center, Boston University School of Medicine
- Joseph P. Mizgerd
- Pulmonary Center, Boston University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-26045-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
The maintenance of T resident memory (TRM) cells within pulmonary tissues is incompletely understood. Here the authors show that antigen presentation by lung epithelial cells maintains function and phenotype of pulmonary TRM cells within specific locational niches.
