Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis

Hiroaki Konishi; Mikihiro Fujiya; Hiroki Tanaka; Nobuhiro Ueno; Kentaro Moriichi; Junpei Sasajima; Katsuya Ikuta; Hiroaki Akutsu; Hiroki Tanabe; Yutaka Kohgo

doi:10.1038/ncomms12365

Nature Communications (Aug 2016)

Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis

Hiroaki Konishi,
Mikihiro Fujiya,
Hiroki Tanaka,
Nobuhiro Ueno,
Kentaro Moriichi,
Junpei Sasajima,
Katsuya Ikuta,
Hiroaki Akutsu,
Hiroki Tanabe,
Yutaka Kohgo

Affiliations

Hiroaki Konishi: Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University
Mikihiro Fujiya: Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University
Hiroki Tanaka: Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University
Nobuhiro Ueno: Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University
Kentaro Moriichi: Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University
Junpei Sasajima: Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University
Katsuya Ikuta: Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University
Hiroaki Akutsu: Center for Advanced Research and Education, Asahikawa Medical University
Hiroki Tanabe: Department of Gastroenterology, International University of Health and Welfare Hospital
Yutaka Kohgo: Department of Gastroenterology, International University of Health and Welfare Hospital

DOI: https://doi.org/10.1038/ncomms12365
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Probiotics have tumour-suppressive effects in cancer cell lines and in animal models. In this study, the authors demonstrate that ferrichrome produced by Lactobacillus caseiATCC334 can suppress colon cancer growth inducing apoptosis via the JNK pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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