Spectrophotometric study on the charge transfer complex between sumatriptan succinate and some π-acceptors and alizarin derivatives

Abstract

A facile, accurate, sensitive and validated spectrophotometric methods for the determination of sumatriptan succinate (SMT) in pure and in dosage forms are described. The methods are based on the formation of charge transfer products between SMT and chromogenic reagents 2,3-dichloro-5,6 dicyano-p-benzoquinone (DDQ), 7,7,8,8-tetracyanoquinodimethane(TCNQ), quinalizarin (Quiz) and alizarin red S (ARS) producing charge transfer complexes which showed an absorption maximum at 461, 841, 567 and 529 nm for DDQ, TCNQ, Quiz and ARS, respectively. The optimization of the reaction conditions such as the type of solvent, reagent concentration and reaction time were investigated. Beer’s law is obeyed in the concentration ranges 1.0-80 mg mL-1. The molar absorptivity, Sandell sensitivity, detection and quantification limits are also calculated. The correlation coefficient was ≥0.9994 with a relative standard deviation (R.S.D.) of ≤ 1.08. The proposed methods were successfully applied for determination of sumatriptan in tablets with good accuracy and precision and without interferences from common additives by applying the standard addition technique. Developed methods have been validated statistically for their accuracy, precision, sensitivity, selectivity, robustness and ruggedness as per ICH guidelines and the results compared favourably with those obtained using the reported method.

Keywords

• Sumatriptan succinate
• DDQ
• TCNQ
• quinalizarin
• alizarin red S
• Charge transfer