Communications Biology (Jan 2022)
gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes
- Nancy Q. Liu,
- Yucheng Lin,
- Liangliang Li,
- Jinxiu Lu,
- Dawei Geng,
- Jiankang Zhang,
- Tea Jashashvili,
- Zorica Buser,
- Jenny Magallanes,
- Jade Tassey,
- Ruzanna Shkhyan,
- Arijita Sarkar,
- Noah Lopez,
- Siyoung Lee,
- Youngjoo Lee,
- Liming Wang,
- Frank A. Petrigliano,
- Ben Van Handel,
- Karen Lyons,
- Denis Evseenko
Affiliations
- Nancy Q. Liu
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Yucheng Lin
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Liangliang Li
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Jinxiu Lu
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Dawei Geng
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Jiankang Zhang
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Tea Jashashvili
- Department of Radiology, Keck School of Medicine of USC, University of Southern California (USC)
- Zorica Buser
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Jenny Magallanes
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Jade Tassey
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Ruzanna Shkhyan
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Arijita Sarkar
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Noah Lopez
- Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California Los Angles (UCLA)
- Siyoung Lee
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Youngjoo Lee
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Liming Wang
- Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University
- Frank A. Petrigliano
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Ben Van Handel
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- Karen Lyons
- Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California Los Angles (UCLA)
- Denis Evseenko
- Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC)
- DOI
- https://doi.org/10.1038/s42003-021-02944-y
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 20
Abstract
Liu et al. demonstrate the role of gp130/STAT3 signalling in the development and homeostasis of chondrocytes in the growth plate and articular cartilage. The authors report that tamoxifen-induced deletion of STAT3 or gp130 in chondrocytes after birth results in defective chondrocyte proliferation, growth plate fusion and stunting, and signs of progressive dysfunction of the articular cartilage, with female mice more strongly affected than males.
