Extracellular cap domain is an essential component of the TRPV1 gating mechanism

Kirill D. Nadezhdin; Arthur Neuberger; Yury A. Nikolaev; Lyle A. Murphy; Elena O. Gracheva; Sviatoslav N. Bagriantsev; Alexander I. Sobolevsky

doi:10.1038/s41467-021-22507-3

Nature Communications (Apr 2021)

Extracellular cap domain is an essential component of the TRPV1 gating mechanism

Kirill D. Nadezhdin,
Arthur Neuberger,
Yury A. Nikolaev,
Lyle A. Murphy,
Elena O. Gracheva,
Sviatoslav N. Bagriantsev,
Alexander I. Sobolevsky

Affiliations

Kirill D. Nadezhdin: Department of Biochemistry and Molecular Biophysics, Columbia University
Arthur Neuberger: Department of Biochemistry and Molecular Biophysics, Columbia University
Yury A. Nikolaev: Department of Cellular and Molecular Physiology, Yale University School of Medicine
Lyle A. Murphy: Department of Cellular and Molecular Physiology, Yale University School of Medicine
Elena O. Gracheva: Department of Cellular and Molecular Physiology, Yale University School of Medicine
Sviatoslav N. Bagriantsev: Department of Cellular and Molecular Physiology, Yale University School of Medicine
Alexander I. Sobolevsky: Department of Biochemistry and Molecular Biophysics, Columbia University

DOI: https://doi.org/10.1038/s41467-021-22507-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 8

Abstract

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Structural and functional characterization of the full-length TRPV1 channel from the thirteen-lined ground squirrel reveal the architecture of the extracellular cap domain and the intracellular C-terminus, and suggest a role of the cap domain in TRPV1 conductance and ion selectivity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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