JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML

Shan-He Yu; Kang-Yong Zhu; Juan Chen; Xiang-Zhen Liu; Peng-Fei Xu; Wu Zhang; Li Yan; He-Zhou Guo; Jiang Zhu

doi:10.1038/s41467-018-05548-z

Nature Communications (Aug 2018)

JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML

Shan-He Yu,
Kang-Yong Zhu,
Juan Chen,
Xiang-Zhen Liu,
Peng-Fei Xu,
Wu Zhang,
Li Yan,
He-Zhou Guo,
Jiang Zhu

Affiliations

Shan-He Yu: State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine
Kang-Yong Zhu: State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine
Juan Chen: State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine
Xiang-Zhen Liu: State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine
Peng-Fei Xu: State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine
Wu Zhang: State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine
Li Yan: State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine
He-Zhou Guo: State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine
Jiang Zhu: State Key Laboratory for Medical Genomics, Shanghai Institute of Hematology and Collaborative Innovation Center of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine

DOI: https://doi.org/10.1038/s41467-018-05548-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Histone demethylase JMJD3 is known to be oncogenic in preleukemic states and T-cell acute lymphocytic leukemia. Here, the authors show that in some acute myeloid leukemia subsets, JMJD3 can actually act as a potential oncorepressor via mediation of C/EBPβ-centered transcriptional programming.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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