Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition

Abstract

Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through non-canonical hedgehog signalling effects on the WNT pathway.

Keywords

• colorectal cancer
• itraconazole
• hedgehog
• wnt
• cancer stem cell
• dormancy
• plasticity
• cell cycle
• heterogeneity