The protein conformational basis of isoflavone biosynthesis

Xiaoqiang Wang; Haiyun Pan; Someswar Sagurthi; Vincent Paris; Chunliu Zhuo; Richard A. Dixon

doi:10.1038/s42003-022-04222-x

Communications Biology (Nov 2022)

The protein conformational basis of isoflavone biosynthesis

Xiaoqiang Wang,
Haiyun Pan,
Someswar Sagurthi,
Vincent Paris,
Chunliu Zhuo,
Richard A. Dixon

Affiliations

Xiaoqiang Wang: BioDiscovery Institute and Department of Biological Sciences, University of North Texas
Haiyun Pan: Conagen, Inc.
Someswar Sagurthi: Department of Genetics & Biotechnology, Osmania University
Vincent Paris: BioDiscovery Institute and Department of Biological Sciences, University of North Texas
Chunliu Zhuo: BioDiscovery Institute and Department of Biological Sciences, University of North Texas
Richard A. Dixon: BioDiscovery Institute and Department of Biological Sciences, University of North Texas

DOI: https://doi.org/10.1038/s42003-022-04222-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 10

Abstract

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The structure and function of two isoflavone biosynthetic enzymes are reported revealing a novel cytochrome P450 conformation and identification of key residues for dual dehydratase and carboxylesterase activities

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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