Establishment of non-integrate induced pluripotent stem cell line CSUASOi006-A, from urine-derived cells of a PRPF8-related dominant retinitis pigmentosa patient

Yalan Zhou; Zekai Cui; Yutong Jing; Shengru Mao; Donglong Chen; Chengcheng Ding; Jianing Gu; Hon fai Chan; Shibo Tang; Jiansu Chen

Stem Cell Research (Dec 2020)

Establishment of non-integrate induced pluripotent stem cell line CSUASOi006-A, from urine-derived cells of a PRPF8-related dominant retinitis pigmentosa patient

Yalan Zhou,
Zekai Cui,
Yutong Jing,
Shengru Mao,
Donglong Chen,
Chengcheng Ding,
Jianing Gu,
Hon fai Chan,
Shibo Tang,
Jiansu Chen

Affiliations

Yalan Zhou: Aier School of Ophthalmology, Central South University, P.R.C., 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, PR China; Aier Eye Institute, 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, PR China
Zekai Cui: Aier Eye Institute, 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, PR China
Yutong Jing: Aier School of Ophthalmology, Central South University, P.R.C., 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, PR China; Aier Eye Institute, 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, PR China
Shengru Mao: Aier School of Ophthalmology, Central South University, P.R.C., 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, PR China; Aier Eye Institute, 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, PR China
Donglong Chen: Aier Eye Institute, 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, PR China
Chengcheng Ding: Aier Eye Institute, 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, PR China
Jianing Gu: Aier Eye Institute, 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, PR China
Hon fai Chan: Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Hong Kong, PR China; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, PR China
Shibo Tang: Aier School of Ophthalmology, Central South University, P.R.C., 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, PR China; Aier Eye Institute, 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, PR China; CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai 200031, PR China; Corresponding authors at: Aier School of Ophthalmology, Central South University, P.R.C., 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, RP China.
Jiansu Chen: Aier School of Ophthalmology, Central South University, P.R.C., 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, PR China; Aier Eye Institute, 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, PR China; Institute of Ophthalmology, Medical College, Jinan University, Guangzhou 510632, PR China; Corresponding authors at: Aier School of Ophthalmology, Central South University, P.R.C., 18th Floor, the New Century Building, #198 Furong Middle Road, Changsha, Hunan 410015, RP China.

Journal volume & issue: Vol. 49
p. 102041

Abstract

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Retinitis pigmentosa (RP) is a group of inherited retinal disorders characterized by the progressive photoreceptors and pigment epithelial cells dysfunction. Here, we report the human induced pluripotent stem cell line (iPSC) CSUASOi006-A, generated from urine-derived cells (UCs) of a 17-year-old male patient with clinically diagnosed RP carrying point mutation (c.C5792T) in the pre-mRNA processing factor 8 gene (PRPF8). The newly derived CSUASOi006-A cell line has the patient’s same mutation (c.C5792T) and could provide useful resources for studying the pathogenic mechanism of PRPF8-related RP.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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