Nature Communications (Mar 2022)
Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis
- Corina N. D’Alessandro-Gabazza,
- Taro Yasuma,
- Tetsu Kobayashi,
- Masaaki Toda,
- Ahmed M. Abdel-Hamid,
- Hajime Fujimoto,
- Osamu Hataji,
- Hiroki Nakahara,
- Atsuro Takeshita,
- Kota Nishihama,
- Tomohito Okano,
- Haruko Saiki,
- Yuko Okano,
- Atsushi Tomaru,
- Valeria Fridman D’Alessandro,
- Miyako Shiraishi,
- Akira Mizoguchi,
- Ryoichi Ono,
- Junpei Ohtsuka,
- Masayuki Fukumura,
- Tetsuya Nosaka,
- Xuenan Mi,
- Diwakar Shukla,
- Kensuke Kataoka,
- Yasuhiro Kondoh,
- Masaki Hirose,
- Toru Arai,
- Yoshikazu Inoue,
- Yutaka Yano,
- Roderick I. Mackie,
- Isaac Cann,
- Esteban C. Gabazza
Affiliations
- Corina N. D’Alessandro-Gabazza
- Department of Immunology, Mie University Faculty and Graduate School of Medicine
- Taro Yasuma
- Department of Immunology, Mie University Faculty and Graduate School of Medicine
- Tetsu Kobayashi
- Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine
- Masaaki Toda
- Department of Immunology, Mie University Faculty and Graduate School of Medicine
- Ahmed M. Abdel-Hamid
- Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana–Champaign
- Hajime Fujimoto
- Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine
- Osamu Hataji
- Respiratory Center, Matsusaka Municipal Hospital
- Hiroki Nakahara
- Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine
- Atsuro Takeshita
- Department of Immunology, Mie University Faculty and Graduate School of Medicine
- Kota Nishihama
- Department of Diabetes and Endocrinology, Mie University Faculty and Graduate School of Medicine
- Tomohito Okano
- Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine
- Haruko Saiki
- Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine
- Yuko Okano
- Department of Immunology, Mie University Faculty and Graduate School of Medicine
- Atsushi Tomaru
- Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine
- Valeria Fridman D’Alessandro
- Department of Immunology, Mie University Faculty and Graduate School of Medicine
- Miyako Shiraishi
- Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana–Champaign
- Akira Mizoguchi
- Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine
- Ryoichi Ono
- Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine
- Junpei Ohtsuka
- Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine
- Masayuki Fukumura
- Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine
- Tetsuya Nosaka
- Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine
- Xuenan Mi
- Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign
- Diwakar Shukla
- Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign
- Kensuke Kataoka
- Department of Respiratory Medicine and Allergy, Tosei General Hospital
- Yasuhiro Kondoh
- Department of Respiratory Medicine and Allergy, Tosei General Hospital
- Masaki Hirose
- Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center
- Toru Arai
- Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center
- Yoshikazu Inoue
- Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center
- Yutaka Yano
- Department of Diabetes and Endocrinology, Mie University Faculty and Graduate School of Medicine
- Roderick I. Mackie
- Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana–Champaign
- Isaac Cann
- Carl R. Woese Institute for Genomic Biology (Microbiome Metabolic Engineering), University of Illinois at Urbana–Champaign
- Esteban C. Gabazza
- Department of Immunology, Mie University Faculty and Graduate School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-29064-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 23
Abstract
Here, the authors show that treatment with a monoclonal neutralizing antibody against the lung microbiota-derived proapoptotic peptide corisin ameliorates acute exacerbation of pulmonary fibrosis and severity of endotoxin-induced acute lung injury in mice.
