Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres

Barbara Breznik; Meng-Wei Ko; Christopher Tse; Po-Chun Chen; Emanuela Senjor; Bernarda Majc; Anamarija Habič; Nicolas Angelillis; Metka Novak; Vera Župunski; Jernej Mlakar; David Nathanson; Anahid Jewett

doi:10.1038/s42003-022-03402-z

Communications Biology (May 2022)

Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres

Barbara Breznik,
Meng-Wei Ko,
Christopher Tse,
Po-Chun Chen,
Emanuela Senjor,
Bernarda Majc,
Anamarija Habič,
Nicolas Angelillis,
Metka Novak,
Vera Župunski,
Jernej Mlakar,
David Nathanson,
Anahid Jewett

Affiliations

Barbara Breznik: Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry
Meng-Wei Ko: Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry
Christopher Tse: Department of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine
Po-Chun Chen: Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry
Emanuela Senjor: Department of Biotechnology, Jožef Stefan Institute
Bernarda Majc: Department of Genetic Toxicology and Cancer Biology, National Institute of Biology
Anamarija Habič: Department of Genetic Toxicology and Cancer Biology, National Institute of Biology
Nicolas Angelillis: Department of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine
Metka Novak: Department of Genetic Toxicology and Cancer Biology, National Institute of Biology
Vera Župunski: Chair of Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana
Jernej Mlakar: Institute of Pathology, Faculty of Medicine, University of Ljubljana
David Nathanson: Department of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine
Anahid Jewett: Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry

DOI: https://doi.org/10.1038/s42003-022-03402-z
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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“Super-charged” NK cells kill patient-derived glioblastoma stem-like cells (GSLCs) in 2D and 3D tumor models, secrete IFN-γ and upregulate the surface expression of CD54 and MHC class I in GSLCs.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal