Nature Communications (Jul 2021)
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
- L. Vanderbeke,
- P. Van Mol,
- Y. Van Herck,
- F. De Smet,
- S. Humblet-Baron,
- K. Martinod,
- A. Antoranz,
- I. Arijs,
- B. Boeckx,
- F. M. Bosisio,
- M. Casaer,
- D. Dauwe,
- W. De Wever,
- C. Dooms,
- E. Dreesen,
- A. Emmaneel,
- J. Filtjens,
- M. Gouwy,
- J. Gunst,
- G. Hermans,
- S. Jansen,
- K. Lagrou,
- A. Liston,
- N. Lorent,
- P. Meersseman,
- T. Mercier,
- J. Neyts,
- J. Odent,
- D. Panovska,
- P. A. Penttila,
- E. Pollet,
- P. Proost,
- J. Qian,
- K. Quintelier,
- J. Raes,
- S. Rex,
- Y. Saeys,
- J. Sprooten,
- S. Tejpar,
- D. Testelmans,
- K. Thevissen,
- T. Van Buyten,
- J. Vandenhaute,
- S. Van Gassen,
- L. C. Velásquez Pereira,
- R. Vos,
- B. Weynand,
- A. Wilmer,
- J. Yserbyt,
- A. D. Garg,
- P. Matthys,
- C. Wouters,
- D. Lambrechts,
- E. Wauters,
- J. Wauters
Affiliations
- L. Vanderbeke
- Laboratory of Clinical Bacteriology and Mycology, Department of Microbiology, Immunology and Transplantation, KU Leuven
- P. Van Mol
- Laboratory of Translational Genetics, Department of Human Genetics, VIB-KU Leuven
- Y. Van Herck
- Laboratory of Experimental Oncology, Department of Oncology, KU Leuven
- F. De Smet
- Laboratory for Precision Cancer Medicine, Translational Cell and Tissue Research, Department of Imaging & Pathology, KU Leuven
- S. Humblet-Baron
- Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven
- K. Martinod
- Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven
- A. Antoranz
- Laboratory for Precision Cancer Medicine, Translational Cell and Tissue Research, Department of Imaging & Pathology, KU Leuven
- I. Arijs
- Laboratory of Translational Genetics, Department of Human Genetics, VIB-KU Leuven
- B. Boeckx
- Laboratory of Translational Genetics, Department of Human Genetics, VIB-KU Leuven
- F. M. Bosisio
- Translational Cell & Tissue Research, Department of Imaging & Pathology, KU Leuven
- M. Casaer
- Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven
- D. Dauwe
- Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven
- W. De Wever
- Radiology, Department of Imaging & Pathology, KU Leuven
- C. Dooms
- Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven
- E. Dreesen
- Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven
- A. Emmaneel
- Department of Applied Mathematics, Computer Science and Statistics, VIB-UGent Center for Inflammation Research, VIB-UGent
- J. Filtjens
- Laboratory of Immunobiology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- M. Gouwy
- Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- J. Gunst
- Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven
- G. Hermans
- Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven
- S. Jansen
- Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- K. Lagrou
- Laboratory of Clinical Bacteriology and Mycology, Department of Microbiology, Immunology and Transplantation, KU Leuven
- A. Liston
- Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham Research Campus
- N. Lorent
- Department of Pneumology, University Hospitals Leuven
- P. Meersseman
- Laboratory for Clinical Infectious and Inflammatory Disorders, Department of Microbiology, Immunology and Transplantation, KU Leuven
- T. Mercier
- Laboratory of Clinical Bacteriology and Mycology, Department of Microbiology, Immunology and Transplantation, KU Leuven
- J. Neyts
- Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- J. Odent
- Department of Internal Medicine, University Hospitals Leuven
- D. Panovska
- Laboratory for Precision Cancer Medicine, Translational Cell and Tissue Research, Department of Imaging & Pathology, KU Leuven
- P. A. Penttila
- KU Leuven Flow & Mass Cytometry Facility, KU Leuven
- E. Pollet
- Department of Internal Medicine, University Hospitals Leuven
- P. Proost
- Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- J. Qian
- Laboratory of Translational Genetics, Department of Human Genetics, VIB-KU Leuven
- K. Quintelier
- Department of Applied Mathematics, Computer Science and Statistics, VIB-UGent Center for Inflammation Research, VIB-UGent
- J. Raes
- Laboratory of Molecular Bacteriology (Rega Institute), Department of Microbiology, Immunology and Transplantation, KU Leuven, and VIB Center for Microbiology
- S. Rex
- Anesthesiology and Algology, Department of Cardiovascular Sciences, KU Leuven
- Y. Saeys
- Department of Applied Mathematics, Computer Science and Statistics, VIB-UGent Center for Inflammation Research, VIB-UGent
- J. Sprooten
- Laboratory for Cell Stress & Immunity (CSI), Department of Cellular and Molecular Medicine (CMM), KU Leuven
- S. Tejpar
- Molecular Digestive Oncology, Department of Oncology, KU Leuven
- D. Testelmans
- Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven
- K. Thevissen
- Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems (M2S), KU Leuven
- T. Van Buyten
- Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- J. Vandenhaute
- Laboratory of Immunobiology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- S. Van Gassen
- Department of Applied Mathematics, Computer Science and Statistics, VIB-UGent Center for Inflammation Research, VIB-UGent
- L. C. Velásquez Pereira
- Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven
- R. Vos
- Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven
- B. Weynand
- Translational Cell & Tissue Research, Department of Imaging & Pathology, KU Leuven
- A. Wilmer
- Laboratory for Clinical Infectious and Inflammatory Disorders, Department of Microbiology, Immunology and Transplantation, KU Leuven
- J. Yserbyt
- Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven
- A. D. Garg
- Laboratory for Cell Stress & Immunity (CSI), Department of Cellular and Molecular Medicine (CMM), KU Leuven
- P. Matthys
- Laboratory of Immunobiology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- C. Wouters
- Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven
- D. Lambrechts
- Laboratory of Translational Genetics, Department of Human Genetics, VIB-KU Leuven
- E. Wauters
- Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven
- J. Wauters
- Laboratory for Clinical Infectious and Inflammatory Disorders, Department of Microbiology, Immunology and Transplantation, KU Leuven
- DOI
- https://doi.org/10.1038/s41467-021-24360-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
The host immune response plays a critical role in the immunopathology of SARS-CoV2. Here the authors combine a systems biology approach to implicate monocytes as key drivers of cytokine storm and disturbed neutrophil activation in COVID-19 disease severity.
