Nature Communications (Nov 2019)
LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription
- Hamed Yari,
- Lei Jin,
- Liu Teng,
- Yufang Wang,
- Yongyan Wu,
- Guang Zhi Liu,
- Wei Gao,
- Jin Liang,
- Yanfeng Xi,
- Yu Chen Feng,
- Chunming Zhang,
- Yuan Yuan Zhang,
- Hessam Tabatabaee,
- Ting La,
- Rui Hong Yang,
- Fu Hua Wang,
- Xu Guang Yan,
- Margaret Farrelly,
- Rodney Scott,
- Tao Liu,
- Rick F. Thorne,
- Su Tang Guo,
- Xu Dong Zhang
Affiliations
- Hamed Yari
- School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of Newcastle
- Lei Jin
- School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of Newcastle
- Liu Teng
- Translational Research Institute, Henan Provincial People’s Hospital, The Academy of Medical Sciences, Zhengzhou University
- Yufang Wang
- Department of Pathophysiology, School of Preclinical and Forensic Medicine, Sichuan University
- Yongyan Wu
- Department of Otolaryngology, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, the first affiliated hospital, Shanxi Medical University
- Guang Zhi Liu
- Translational Research Institute, Henan Provincial People’s Hospital, The Academy of Medical Sciences, Zhengzhou University
- Wei Gao
- Department of Otolaryngology, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, the first affiliated hospital, Shanxi Medical University
- Jin Liang
- Department of Molecular Biology, Department of Pathology, Shanxi Cancer Hospital and Institute, Shanxi Medical University
- Yanfeng Xi
- Department of Molecular Biology, Department of Pathology, Shanxi Cancer Hospital and Institute, Shanxi Medical University
- Yu Chen Feng
- School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of Newcastle
- Chunming Zhang
- Department of Otolaryngology, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, the first affiliated hospital, Shanxi Medical University
- Yuan Yuan Zhang
- School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of Newcastle
- Hessam Tabatabaee
- School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of Newcastle
- Ting La
- School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of Newcastle
- Rui Hong Yang
- Department of Molecular Biology, Department of Pathology, Shanxi Cancer Hospital and Institute, Shanxi Medical University
- Fu Hua Wang
- Department of Molecular Biology, Department of Pathology, Shanxi Cancer Hospital and Institute, Shanxi Medical University
- Xu Guang Yan
- School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of Newcastle
- Margaret Farrelly
- School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of Newcastle
- Rodney Scott
- School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of Newcastle
- Tao Liu
- Children’s Cancer Institute Australia for Medical Research, University of New South Wales
- Rick F. Thorne
- School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of Newcastle
- Su Tang Guo
- Department of Molecular Biology, Department of Pathology, Shanxi Cancer Hospital and Institute, Shanxi Medical University
- Xu Dong Zhang
- School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of Newcastle
- DOI
- https://doi.org/10.1038/s41467-019-13313-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
The regenerating islet-derived (REG) protein family suppresses cell death and promotes cell proliferation. Here the authors report that the lncRNA REG1CP forms an RNA–DNA triplex at the promoter of REG3A gene to increase its expression.
