Nature Communications (Jul 2020)
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
- Maximilian Strunz,
- Lukas M. Simon,
- Meshal Ansari,
- Jaymin J. Kathiriya,
- Ilias Angelidis,
- Christoph H. Mayr,
- George Tsidiridis,
- Marius Lange,
- Laura F. Mattner,
- Min Yee,
- Paulina Ogar,
- Arunima Sengupta,
- Igor Kukhtevich,
- Robert Schneider,
- Zhongming Zhao,
- Carola Voss,
- Tobias Stoeger,
- Jens H. L. Neumann,
- Anne Hilgendorff,
- Jürgen Behr,
- Michael O’Reilly,
- Mareike Lehmann,
- Gerald Burgstaller,
- Melanie Königshoff,
- Harold A. Chapman,
- Fabian J. Theis,
- Herbert B. Schiller
Affiliations
- Maximilian Strunz
- Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL)
- Lukas M. Simon
- Institute of Computational Biology, Helmholtz Zentrum München
- Meshal Ansari
- Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL)
- Jaymin J. Kathiriya
- Biomedical Center, University of California San Francisco
- Ilias Angelidis
- Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL)
- Christoph H. Mayr
- Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL)
- George Tsidiridis
- Institute of Computational Biology, Helmholtz Zentrum München
- Marius Lange
- Institute of Computational Biology, Helmholtz Zentrum München
- Laura F. Mattner
- Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL)
- Min Yee
- Department of Pediatrics, University of Rochester
- Paulina Ogar
- Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL)
- Arunima Sengupta
- Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL)
- Igor Kukhtevich
- Institute of Functional Epigenetics, Helmholtz Zentrum München
- Robert Schneider
- Institute of Functional Epigenetics, Helmholtz Zentrum München
- Zhongming Zhao
- Center for Precision Health, School of Biomedical Informatics, University of Texas Health Science Center
- Carola Voss
- Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL)
- Tobias Stoeger
- Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL)
- Jens H. L. Neumann
- Institute of Pathology, Ludwig Maximilians University Hospital Munich
- Anne Hilgendorff
- Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL)
- Jürgen Behr
- Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL)
- Michael O’Reilly
- Department of Pediatrics, University of Rochester
- Mareike Lehmann
- Comprehensive Pneumology Center (CPC), Research Unit Lung Repair and Regeneration, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL)
- Gerald Burgstaller
- Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL)
- Melanie Königshoff
- Comprehensive Pneumology Center (CPC), Research Unit Lung Repair and Regeneration, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL)
- Harold A. Chapman
- Biomedical Center, University of California San Francisco
- Fabian J. Theis
- Institute of Computational Biology, Helmholtz Zentrum München
- Herbert B. Schiller
- Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL)
- DOI
- https://doi.org/10.1038/s41467-020-17358-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 20
Abstract
Injury repair is characterized by the generation of transient cell states important for tissue recovery. Here, the authors present a single cell RNA-seq map of recovery from bleomycin lung injury in mice and uncover a Krt8+ transitional stem cell state that precedes the regeneration of AT1 cells and persists in human lung fibrosis.
