Molecules (Mar 2011)

Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents

  • Jing-Ping Liou,
  • Jang-Yang Chang,
  • Chih-Ying Nien,
  • Cheng-Chih Hsieh,
  • Chi-Yen Chang,
  • Ching-Chuan Kuo,
  • Hsueh-Yun Lee

DOI
https://doi.org/10.3390/molecules16032274
Journal volume & issue
Vol. 16, no. 3
pp. 2274 – 2284

Abstract

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A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.

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