Nature Communications (Aug 2022)
Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent
- Liang Dong,
- Yun-Jun Xu,
- Cong Sui,
- Yang Zhao,
- Li-Bo Mao,
- Denis Gebauer,
- Rose Rosenberg,
- Jonathan Avaro,
- Ya-Dong Wu,
- Huai-Ling Gao,
- Zhao Pan,
- Hui-Qin Wen,
- Xu Yan,
- Fei Li,
- Yang Lu,
- Helmut Cölfen,
- Shu-Hong Yu
Affiliations
- Liang Dong
- Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of China
- Yun-Jun Xu
- Department of Radiology, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China
- Cong Sui
- Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of China
- Yang Zhao
- Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of China
- Li-Bo Mao
- Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of China
- Denis Gebauer
- Institute of Inorganic Chemistry, Leibniz Universität Hannover
- Rose Rosenberg
- Physical Chemistry, Department of Chemistry, University of Konstanz
- Jonathan Avaro
- Scientist - Center for X-ray Analytics, Empa - Swiss Federal Laboratories for Materials Science and Technology
- Ya-Dong Wu
- Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology
- Huai-Ling Gao
- Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of China
- Zhao Pan
- Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of China
- Hui-Qin Wen
- Department of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University
- Xu Yan
- Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology
- Fei Li
- Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology
- Yang Lu
- Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology
- Helmut Cölfen
- Physical Chemistry, Department of Chemistry, University of Konstanz
- Shu-Hong Yu
- Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, University of Science and Technology of China
- DOI
- https://doi.org/10.1038/s41467-022-32615-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Sensitive, biocompatible and stable contrast agents for MRI are in demand. Here, the authors combine gadolinium ions with amorphous calcium carbonate to make stable paramagnetic amorphous carbonate nanoclusters with high MRI contrast and significantly improved biocompatibility over commercial gadolinium-based agents.
