Association of proinflammatory cytokine IL-20 gene polymorphism with psoriasis in north Indian population

Abstract

Background: IL-20 plays an important role in the inflammatory and hyperproliferative dermatosis of psoriasis.Aim: The aim of the study was to determine whether the IL-20 gene polymorphism, haplotype and serum level confer pathogenesis of psoriasis.Subjects and methods: 200 psoriatic patients and 200 controls were genotyped for four IL-20 polymorphic sites by polymerase chain reaction. Serum levels of IL-20 were measured by ELISA. Results: Our results demonstrated that polymorphism of IL-120 −1380 A/G (adjusted∗ OR 5.52; (95% CI = 2.43–12.55) was found to be in association with increased risk of psoriasis while as IL-20–1462 G/A (adjusted∗ OR = 0.11 95; (95% CI = 0.03–0.34) was found to be in association with decreased risk of psoriasis and IL-20–1053 G/T adjusted∗ OR 1.99; (95% CI = 0.86–4.64), IL-20–3978 T/C(adjusted∗ OR = 12.87; (95% CI = 0.97–79.54) polymorphism does not show any significant association with the risk of psoriasis. HT4 TG haplotype is associated with decreased risk of psoriasis. Serum IL-20 level significantly increases in patients, as compared to controls with non-significant correlation between serum IL-20 and psoriasis severity. Conclusion: These findings suggest that IL-20 polymorphism have significant role towards the susceptibility of psoriasis in north Indian population. Evaluating the role of IL-20 cytokine in pathogenesis of psoriasis will prove helpful for the development of psoriasis management. Keywords: Cytokine, Polymorphism, IL-20, ELISA, Psoriasis