Malignant melanoma of the nasal septum, a rare tumor, occurring in a 54-year-old patient after hereditary retinoblastoma treatment

Abstract

Windinmanégdé Pierre Djiguimdé,1 Ibrahim Abib Diomandé,2 Nicolas Bonnin,3 Nicolas Saroul,4 Abdoulaye Touré,5 Jérôme Sanou,1 Paté Sankara,1 Marc Russier,4 Laurent Gilain,4 Ahgbatouhabéba Ahnoux-Zabsonré,1 Nonfounikoun Meda,1 Franck Bacin3 1Ophthalmology Department, University Hospital Yalgado Ouédraogo, Ouagadougou, Burkina Faso, 2Ophthalmology Department, University Hospital of Bouaké, University Alassane Ouattara, Bouaké, Cote d'Ivoire, 3Ophthalmology Department, 4Otorhinolaryngology Department, University Hospital Clermont-Ferrand, Clermont-Ferrand, France; 5Radiology Department, University Hospital of Yopougon, University Félix Houphouët Boigny, Abidjan, Côte d'Ivoire Abstract: The authors report a case of a malignant melanoma of the nasal cavity that is a rare tumor and very aggressive, constituting 1% of all melanomas. It appeared in a patient 54 years after he was treated for a hereditary retinoblastoma. Its symptoms are nonspecific, and often marked by epistaxis. Its diagnosis is histological, supported by immunohistochemistry. Its prognosis is often unfavorable, and characterized by the occurrence of metastases and recurrences. Because of the risk of secondary cancer that exists in any survivor of hereditary retinoblastoma, we must think of possible mucosal melanoma of the nasal sinus in these patients in cases of chronic epistaxis. The prognosis of this tumor depends on its early diagnosis and surgical treatment. Keywords: retinoblastoma, epistaxis, immunohistochemistry, nasosinusal melanoma, hereditary cancer 

Keywords

• retinoblastoma
• epistaxis
• immunohistochemistry
• naso-sinusal melanoma