Nucleoid remodeling during environmental adaptation is regulated by HU-dependent DNA bundling

Soumya G. Remesh; Subhash C. Verma; Jian-Hua Chen; Axel A. Ekman; Carolyn A. Larabell; Sankar Adhya; Michal Hammel

doi:10.1038/s41467-020-16724-5

Nature Communications (Jun 2020)

Nucleoid remodeling during environmental adaptation is regulated by HU-dependent DNA bundling

Soumya G. Remesh,
Subhash C. Verma,
Jian-Hua Chen,
Axel A. Ekman,
Carolyn A. Larabell,
Sankar Adhya,
Michal Hammel

Affiliations

Soumya G. Remesh: Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute
Subhash C. Verma: Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute
Jian-Hua Chen: Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory
Axel A. Ekman: Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory
Carolyn A. Larabell: Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory
Sankar Adhya: Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute
Michal Hammel: Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory

DOI: https://doi.org/10.1038/s41467-020-16724-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

Read online

HU is among the most conserved and abundant nucleoid-associated proteins in eubacteria. Here the authors investigate the role of histone-like proteins (HU) in the 3D organization of the bacteria DNA and show via soft X-ray tomography the process of nucleoid remodeling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal