Frontiers in Pharmacology (Dec 2024)
Influence of inhaled nitric oxide on bronchopulmonary dysplasia in preterm infants with PPHN or HRF at birth: a propensity score matched study
- Xue-rong Huang,
- Xue-rong Huang,
- Xue-rong Huang,
- Lian Wang,
- Lian Wang,
- Lian Wang,
- Guo-bao Liang,
- Guo-bao Liang,
- Guo-bao Liang,
- Sheng-qian Huang,
- Bao-ying Feng,
- Lu Zhu,
- Xu-fang Fan,
- Mu-lin Yao,
- Jing Zhang,
- Meng-jiao Wang,
- Zhi Zheng,
- Zhi Zheng,
- Zhi Zheng,
- Yao Zhu,
- Yao Zhu,
- Yao Zhu,
- Wen-li Duan,
- Zhan-kui Li,
- Jian Mao,
- Li Ma,
- Fa-lin Xu,
- Fan Wu,
- Qiu-fen Wei,
- Ling Liu,
- Xin-zhu Lin,
- Xin-zhu Lin,
- Xin-zhu Lin
Affiliations
- Xue-rong Huang
- Department of Neonatology, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China
- Xue-rong Huang
- Department of Pediatrics, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China
- Xue-rong Huang
- Xiamen Key Laboratory of Perinatal-Neonatal Infection, Xiamen, China
- Lian Wang
- Department of Neonatology, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China
- Lian Wang
- Department of Pediatrics, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China
- Lian Wang
- Xiamen Key Laboratory of Perinatal-Neonatal Infection, Xiamen, China
- Guo-bao Liang
- Department of Neonatology, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China
- Guo-bao Liang
- Department of Pediatrics, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China
- Guo-bao Liang
- Xiamen Key Laboratory of Perinatal-Neonatal Infection, Xiamen, China
- Sheng-qian Huang
- Department of Neonatology, Guiyang Maternal and Child Healthcare Hospital, Guiyang Children’s Hospital, Guiyang, Guizhou, China
- Bao-ying Feng
- Department of Neonatology, Maternal and Child Health Hospital of the Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
- Lu Zhu
- Department of Neonatology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
- Xu-fang Fan
- Department of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
- Mu-lin Yao
- Department of Neonatology, Children’s Hospital of Hebei province, Shijiazhuang, Hebei, China
- Jing Zhang
- Department of Neonatology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
- Meng-jiao Wang
- 0Department of Neonatology, Northwest Women’s and Children’s Hospital, Xi’an, Shanxi, China
- Zhi Zheng
- Department of Neonatology, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China
- Zhi Zheng
- Department of Pediatrics, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China
- Zhi Zheng
- Xiamen Key Laboratory of Perinatal-Neonatal Infection, Xiamen, China
- Yao Zhu
- Department of Neonatology, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China
- Yao Zhu
- Department of Pediatrics, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China
- Yao Zhu
- Xiamen Key Laboratory of Perinatal-Neonatal Infection, Xiamen, China
- Wen-li Duan
- Department of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
- Zhan-kui Li
- 0Department of Neonatology, Northwest Women’s and Children’s Hospital, Xi’an, Shanxi, China
- Jian Mao
- Department of Neonatology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
- Li Ma
- Department of Neonatology, Children’s Hospital of Hebei province, Shijiazhuang, Hebei, China
- Fa-lin Xu
- Department of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
- Fan Wu
- Department of Neonatology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
- Qiu-fen Wei
- Department of Neonatology, Maternal and Child Health Hospital of the Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
- Ling Liu
- Department of Neonatology, Guiyang Maternal and Child Healthcare Hospital, Guiyang Children’s Hospital, Guiyang, Guizhou, China
- Xin-zhu Lin
- Department of Neonatology, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China
- Xin-zhu Lin
- Department of Pediatrics, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China
- Xin-zhu Lin
- Xiamen Key Laboratory of Perinatal-Neonatal Infection, Xiamen, China
- DOI
- https://doi.org/10.3389/fphar.2024.1515030
- Journal volume & issue
-
Vol. 15
Abstract
BackgroundBronchopulmonary Dysplasia (BPD) is a chronic lung disease affecting preterm infants, with limited prevention and treatment options. Inhaled Nitric Oxide (iNO) is sometimes used to treat Persistent Pulmonary Hypertension of the Newborn (PPHN) and Hypoxemic Respiratory Failure (HRF), and its impact on BPD development remains debated.ObjectiveTo assess whether iNO-related factors are potential contributors to the development of BPD Grade Ⅱ-Ⅲ in very premature infants (VPI) diagnosed with PPHN or HRF at birth using Propensity Score Matching (PSM).MethodsWe conducted a retrospective cohort study of infants born at 22–32 weeks gestation with PPHN or HRF, treated with iNO for over 3 h. PSM matched groups by gestational age, birth weight, and gender, etc. Multivariate logistic regression evaluated the association between iNO treatment and BPD outcomes to identify influencing factors, while Restricted Cubic Spline (RCS) and mediation analysis examined iNO dose effects and potential mediators like mechanical ventilation time and oxygenation index (OI).ResultsA higher initial iNO dose was significantly associated with a reduced risk of BPD Grade Ⅱ-Ⅲ (adjusted OR = 0.68, 95% CI: 0.52–0.89, p < 0.01). Additionally, administration of iNO within the first 7 days of life was identified as an important influencing factor No significant mediation effects were observed for factors such as mechanical ventilation time and OI.ConclusionA higher initial iNO dose within the first 7 days was associated with a reduced risk of BPD Grade Ⅱ-Ⅲ in VPI with PPHN or HRF.
Keywords
- BPD (bronchopulmonary dysplasia)
- nitric oxide - NO
- very premature infant
- PPHN (persistent pulmonary hypertension of the newborn)
- hypoxemic respiratory failure
