APOBEC3 as a driver of genetic intratumor heterogeneity

Abstract

Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.

Keywords

• apobec
• non-small cell lung cancer
• breast cancer
• intratumor heterogeneity
• chromosomal instability