MYCOBACTERIUM TUBERCULOSIS VIRULENCE

B. I. Vishnevskiy; O. A. Manicheva; P. K. Yablonskiy

doi:10.15789/2220-7619-2014-4-319-330

Инфекция и иммунитет (Feb 2015)

MYCOBACTERIUM TUBERCULOSIS VIRULENCE

B. I. Vishnevskiy,
O. A. Manicheva,
P. K. Yablonskiy

Affiliations

B. I. Vishnevskiy: St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russian Federation 194064, Russian Federation, St. Petersburg, olitekhnicheskaya str., 32, St. Petersburg Research Institute of Phthisiopulmonology. Phone: +7 (812) 297-16-26. Fax: +7 (812) 237-16-26
O. A. Manicheva: St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russian Federation
P. K. Yablonskiy: St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russian Federation

DOI: https://doi.org/10.15789/2220-7619-2014-4-319-330
Journal volume & issue: Vol. 4, no. 4
pp. 319 – 330

Abstract

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This review presents recent data on the genetic determinants and the virulence factors of Mycobacterium tuberculosis (MBT). The mechanisms of adaptation of the pathogen in the host organism and alterative manifestations are described as well as the relationship of virulence, drug resistance and the genetic affiliation of MBT are analyzed in thearticle. It was demonstrated the clinical and prognostic significance of Mycobacterium tuberculosis virulence. The cyclic changes in MBT virulence coincide with the rise and fall of the incidence of tuberculosis has been established. Some virulence factors are targets to create fundamentally new anti-TB drugs.

Published in Инфекция и иммунитет

ISSN: 2220-7619 (Print); 2313-7398 (Online)
Publisher: Sankt-Peterburg : NIIÈM imeni Pastera
Country of publisher: Russian Federation
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://iimmun.ru/iimm/index

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