Structure of human cytomegalovirus virion reveals host tRNA binding to capsid-associated tegument protein pp150

Yun-Tao Liu; David Strugatsky; Wei Liu; Z. Hong Zhou

doi:10.1038/s41467-021-25791-1

Nature Communications (Sep 2021)

Structure of human cytomegalovirus virion reveals host tRNA binding to capsid-associated tegument protein pp150

Yun-Tao Liu,
David Strugatsky,
Wei Liu,
Z. Hong Zhou

Affiliations

Yun-Tao Liu: California NanoSystems Institute, University of California, Los Angeles
David Strugatsky: California NanoSystems Institute, University of California, Los Angeles
Wei Liu: California NanoSystems Institute, University of California, Los Angeles
Z. Hong Zhou: California NanoSystems Institute, University of California, Los Angeles

DOI: https://doi.org/10.1038/s41467-021-25791-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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Here, cryo-EM reconstructions of human cytomegalovirus (HCMV) virions reveal host tRNAs associated with the virion’s capsid-bound tegument protein, pp150. tRNA recruitment is mediated by the interactions specific for HCMV only, suggesting the explanation for the absence of such tRNA densities in related herpesviruses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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