Frontiers in Oncology (Aug 2022)

Case report: Salvage capmatinib therapy in KIF5B-MET fusion-positive lung adenocarcinoma with resistance to telisotuzumab vedotin

  • Chien-Yu Lin,
  • Sheng-Huan Wei,
  • Yi-Lin Chen,
  • Chung-Ta Lee,
  • Shang-Yin Wu,
  • Chung-Liang Ho,
  • Dean C. Pavlick,
  • Po-Lan Su,
  • Chien-Chung Lin,
  • Chien-Chung Lin,
  • Chien-Chung Lin

DOI
https://doi.org/10.3389/fonc.2022.919123
Journal volume & issue
Vol. 12

Abstract

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Telisotuzumab vedotin is a MET-targeting antibody–drug conjugate that has demonstrated a good treatment response in patients with EGFR wild-type MET-overexpressing non-squamous non-small cell lung cancer. However, patients have been reported to acquire resistance to this drug, and the subsequent therapy has not been standardized. Here, we present a case of a 56-year-old woman diagnosed with KIF5B-MET fusion-positive non-small cell lung cancer who had a durable response to capmatinib after acquired resistance to telisotuzumab vedotin.

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