Frontiers in Cardiovascular Medicine (Mar 2023)

Use of the cardiopulmonary coupling index based on refined composite multiscale entropy for prognostication of acute type A aortic dissection

  • Zhi-Jie Mao,
  • Wei-Wei Wen,
  • Yi-Chen Han,
  • Wei-hua Dong,
  • Li-juan Shen,
  • Zhou-Qing Huang,
  • Qiang-Li Xie

DOI
https://doi.org/10.3389/fcvm.2023.1126889
Journal volume & issue
Vol. 10

Abstract

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ObjectivesThe aim of this study is to assess the influence of cardiopulmonary coupling (CPC) based on RCMSE on the prediction of complications and death in patients with acute type A aortic dissection (ATAAD).BackgroundThe cardiopulmonary system may be nonlinearly regulated, and its coupling relationship with postoperative risk stratification in ATAAD patients has not been studied.MethodsThis study was a single-center, prospective cohort study (ChiCTR1800018319). We enrolled 39 patients with ATAAD. The outcomes were in-hospital complications and all-cause readmission or death at 2 years.ResultsOf the 39 participants, 16 (41.0%) developed complications in the hospital, and 15 (38.5%) died or were readmitted to the hospital during the two-year follow-up. When CPC-RCMSE was used to predict in-hospital complications in ATAAD patients, the AUC was 0.853 (p < 0.001). When CPC-RCMSE was used to predict all-cause readmission or death at 2 years, the AUC was 0.731 (p < 0.05). After adjusting for age, sex, ventilator support (days), and special care time (days), CPC-RCMSE remained an independent predictor of in-hospital complications in patients with ATAAD [adjusted OR: 0.8 (95% CI, 0.68–0.94)].ConclusionCPC-RCMSE was an independent predictor of in-hospital complications and all-cause readmission or death in patients with ATAAD.

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