LEIGH SYNDROME DRUG DISCOVERY WITH INDUCED NEURONS AND MIDBRAIN ORGANOIDS UNVEILS A REPOSITIONABLE COMPOUND

• Carmen Menacho,
• Satoshi Okawa,
• Laura Petersilie,
• Annette Seibt,
• Markus Schülke,
• Felix Distelmaier,
• Christine R. Rose,
• Antonio Del Sol,
• Alessandro Prigione

Affiliations

Carmen Menacho

University Hospital Düsseldorf, Department Of General Pediatrics, Neonatology And Pediatric Cardiology, Düsseldorf, Germany

Satoshi Okawa

Luxembourg Centre for Systems Biomedicine (LCSB), Computational Biology Group, Luxembourg, Luxembourg

Laura Petersilie

Heinrich Heine University, Institute Of Neurobiology, Düsseldorf, Germany

Annette Seibt

University Hospital Düsseldorf, Department Of General Pediatrics, Neonatology And Pediatric Cardiology, Düsseldorf, Germany

Markus Schülke

Charité-Universitätsmedizin Berlin, Department Of Neuropediatrics, Berlin, Germany

Felix Distelmaier

University Hospital Düsseldorf, Department Of General Pediatrics, Neonatology And Pediatric Cardiology, Düsseldorf, Germany

Christine R. Rose

Heinrich Heine University, Institute Of Neurobiology, Düsseldorf, Germany

Antonio Del Sol

Luxembourg Centre for Systems Biomedicine (LCSB), Computational Biology Group, Luxembourg, Luxembourg

Alessandro Prigione

University Hospital Düsseldorf, Department Of General Pediatrics, Neonatology And Pediatric Cardiology, Düsseldorf, Germany