Journal of Translational Medicine (Dec 2008)

A systematic approach to biomarker discovery; Preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers"

  • Schendel Dolores,
  • Rivoltini Licia,
  • Ribas Antoni,
  • Potter Douglas M,
  • Palucka A Karolina,
  • Masucci Giuseppe,
  • Malyguine Anatoli,
  • Maecker Holden,
  • Maio Michele,
  • Maccalli Cristina,
  • Kirkwood John M,
  • Kleen Thomas O,
  • Janetzki Sylvia,
  • Håkansson Leif,
  • Dhodapkar Madhav,
  • Coukos George,
  • Chaussabel Damien,
  • Wigginton Jon,
  • Wang Ena,
  • Trinchieri Giorgio,
  • Thurin Magdalena,
  • Khleif Samir N,
  • Lee Peter P,
  • Fox Bernard A,
  • Disis Mary L,
  • Butterfield Lisa H,
  • Seliger Barbara,
  • Selvan Senthamil,
  • Slingluff Craig L,
  • Stroncek David F,
  • Streicher Howard,
  • Wu Xifeng,
  • Zeskind Benjamin,
  • Zhao Yingdong,
  • Zocca Mai-Britt,
  • Zwierzina Heinz,
  • Marincola Francesco M

DOI
https://doi.org/10.1186/1479-5876-6-81
Journal volume & issue
Vol. 6, no. 1
p. 81

Abstract

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Abstract The International Society for the Biological Therapy of Cancer (iSBTc) has initiated in collaboration with the United States Food and Drug Administration (FDA) a programmatic look at innovative avenues for the identification of relevant parameters to assist clinical and basic scientists who study the natural course of host/tumor interactions or their response to immune manipulation. The task force has two primary goals: 1) identify best practices of standardized and validated immune monitoring procedures and assays to promote inter-trial comparisons and 2) develop strategies for the identification of novel biomarkers that may enhance our understating of principles governing human cancer immune biology and, consequently, implement their clinical application. Two working groups were created that will report the developed best practices at an NCI/FDA/iSBTc sponsored workshop tied to the annual meeting of the iSBTc to be held in Washington DC in the Fall of 2009. This foreword provides an overview of the task force and invites feedback from readers that might be incorporated in the discussions and in the final document.