The role of CD74 in cardiovascular disease

Qiu-Lin Li; Qiu-Lin Li; Jing Tang; Jing Tang; Jing Tang; Ling Zhao; Ling Zhao; Amanguli Ruze; Amanguli Ruze; Xue-Feng Shan; Xue-Feng Shan; Xiao-Ming Gao; Xiao-Ming Gao; Xiao-Ming Gao

doi:10.3389/fcvm.2022.1049143

Frontiers in Cardiovascular Medicine (Jan 2023)

The role of CD74 in cardiovascular disease

Qiu-Lin Li,
Qiu-Lin Li,
Jing Tang,
Jing Tang,
Jing Tang,
Ling Zhao,
Ling Zhao,
Amanguli Ruze,
Amanguli Ruze,
Xue-Feng Shan,
Xue-Feng Shan,
Xiao-Ming Gao,
Xiao-Ming Gao,
Xiao-Ming Gao

Affiliations

Qiu-Lin Li: State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China
Qiu-Lin Li: Xinjiang Key Laboratory of Medical Animal Model Research, Ürümqi, China
Jing Tang: State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China
Jing Tang: Xinjiang Key Laboratory of Medical Animal Model Research, Ürümqi, China
Jing Tang: Department of Clinical Laboratory, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China
Ling Zhao: State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China
Ling Zhao: Xinjiang Key Laboratory of Medical Animal Model Research, Ürümqi, China
Amanguli Ruze: State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China
Amanguli Ruze: Xinjiang Key Laboratory of Medical Animal Model Research, Ürümqi, China
Xue-Feng Shan: State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China
Xue-Feng Shan: Xinjiang Key Laboratory of Medical Animal Model Research, Ürümqi, China
Xiao-Ming Gao: State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China
Xiao-Ming Gao: Xinjiang Key Laboratory of Medical Animal Model Research, Ürümqi, China
Xiao-Ming Gao: Clinical Medical Research Institute of Xinjiang Medical University, Ürümqi, China

DOI: https://doi.org/10.3389/fcvm.2022.1049143
Journal volume & issue: Vol. 9

Abstract

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Leukocyte differentiation antigen 74 (CD74), also known as invariant chain, is a molecular chaperone of major histocompatibility complex class II (MHC II) molecules involved in antigen presentation. CD74 has recently been shown to be a receptor for the macrophage migration inhibitory factor family proteins (MIF/MIF2). Many studies have revealed that CD74 plays an important role in cardiovascular disease. In this review, we summarize the structure and main functions of CD74 and then focus on the recent research progress on the role of CD74 in cardiovascular diseases. In addition, we also discuss potential treatment strategies that target CD74. Our systematic review of the role of CD74 in cardiovascular disease will fill some knowledge gaps in the field.

Published in Frontiers in Cardiovascular Medicine

ISSN: 2297-055X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.frontiersin.org/journals/cardiovascular-medicine

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Abstract

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