Journal of Chemistry (Jan 2013)

Alkylation and 1,3-Dipolar Cycloaddition of 6-Styryl-4,5-dihydro-2H-pyridazin-3-one: Synthesis of Novel N-Substituted Pyridazinones and Triazolo[4,3-b]pyridazinones

  • Souad Mojahidi,
  • Hanan Sekkak,
  • El Mostapha Rakib,
  • Maria G. P. M. S. Neves,
  • Maria A. F. Faustino,
  • José A. S. Cavaleiro,
  • Hafid Zouihri

DOI
https://doi.org/10.1155/2013/636280
Journal volume & issue
Vol. 2013

Abstract

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Some new N-substituted pyridazinones and triazolo[4,3-b]pyridazinones were synthesized, respectively, by simple alkylation and 1,3-dipolar cycloaddition of pyridazin-3-one with nitrile imines. The regioselectivity of the reactions was ascertained by 1H, 13C NMR spectroscopy and X-ray diffraction of the synthesized compounds.