CHADS-Vasc score and CHADS-Vasc-HS score are poor predictors of in-stent restenosis among patients with coronary drug-eluting stents

Abstract

Objective To evaluate the ability of two scoring systems (CHA 2 DS 2 -VASc score and CHA 2 DS 2 -VASc+hyperlipidaemia+smoking [CHA 2 DS 2 -VASc-HS score]) to predict in-stent restenosis (ISR) among patients undergoing drug-eluting stent (DES) implantation. Methods This retrospective study enrolled patients who underwent coronary angiography to assess coronary artery disease severity secondary to a diagnosis of stable angina or acute coronary syndrome that subsequently underwent DES implantations. Demographic, clinical, angiographic and biochemical parameters were compared between those patients that experienced ISR and those that did not during the study follow-up period. Univariate and multivariate logistic regression analyses were used to evaluate associations between the baseline parameters, the two scoring systems and ISR risk. Results A total of 358 patients (non-ISR group n = 316; ISR group n = 42) participated in the study. Compared with the non-ISR group, more patients in the ISR group had diabetes mellitus and received stents with smaller diameters but longer lengths. There were no significant differences with regard the predictive ability for ISR of either the CHA 2 DS 2 -Vasc or the CHA 2 DS 2 -Vasc-HS scores. Multivariate logistic regression analyses demonstrated that stent diameter, follow-up duration and glycosylated haemoglobin were independent risk factors for ISR. Conclusions The CHA 2 DS 2 -Vasc and CHA 2 DS 2 -Vasc-HS scores did not predict ISR in patients after coronary DES placement.