International Journal of Infectious Diseases (Sep 2021)

Interferon-gamma release assay testing to assess COVID-19 vaccination response in a SARS-CoV-2 seronegative patient on rituximab: a case report

  • Jessica Ferguson,
  • Kanagavel Murugesan,
  • Niaz Banaei,
  • Anne Liu

Journal volume & issue
Vol. 110
pp. 229 – 231

Abstract

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We describe the case of a 44-year-old female patient on rituximab for the treatment of multiple sclerosis with undetectable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG specific antibodies 18 days after the second dose of SARS-CoV-2 vaccine. Interferon-gamma release assay testing for SARS-CoV-2 was positive on day 19, demonstrating a robust T cell-mediated response despite the lack of an antibody-mediated response.

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