CARDIOCYTOPROTECTION PERSPECTIVES WITH ISCHEMIC PRECONDITIONING: HYPOXIA-INDUCED FACTOR 1 — POSSIBLE MOLECULAR MECHANISM AND TARGET FOR PHARMACOTHERAPY

Abstract

The article is focused on the analysis of modern fundamental studies of the preconditioning/preintervention phenomenon in coronary heart disease and heart failure. Brief prerequisites are given for the phenomenon assessment. Molecular and genetic base of the phenomenon presented, as the results of modern experimental works in the area of fundamental medicine and clinical observations of the patients with various cardiovascular diseases. Hypoxia-induced factor 1 — main pathogenetic adaptation factor for hypoxia — plays critical protection role in pathophysiology of coronary heart disease and heart failure, controlling and determining the supply and utilization of oxygen, regulating angiogenesis and vascular remodelling, glucose metabolism and redox exchange. Personalized medicine technology, based on the pharmacogenomics, pharmacoproteomics, makes it to implement fundamental discoveries in medicine to clinical practice.

Keywords

• : hypoxia
• cardioprotection
• prevention
• ischemic heart disease
• personalized medicine