Therapeutic Advances in Hematology (Aug 2023)

Anemia is associated with long-term exposure to PM and its components: a large population-based study in Southwest China

  • Congyuan He,
  • Linshen Xie,
  • Lingxi Gu,
  • Hongyu Yan,
  • Shiyu Feng,
  • Chunmei Zeng,
  • Wangjiu Danzhen,
  • Xuehui Zhang,
  • Mingming Han,
  • Zhifeng Li,
  • Zhuoma Duoji,
  • Bing Guo,
  • Juying Zhang,
  • Feng Hong,
  • Xing Zhao

DOI
https://doi.org/10.1177/20406207231189922
Journal volume & issue
Vol. 14

Abstract

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Background: Anemia is linked to PM 2.5 (particulate matter with aerodynamic diameters of ⩽2.5 μm) exposure, which can increase the risk of various negative health outcomes. It remains unclear which PM 2.5 components are associated with anemia and the respective contribution of each component to this association. Objective: This study aimed at investigating the association between PM 2.5 and anemia in the general population and to identify the most critical PM 2.5 toxic components in this association. Design: Cross-sectional study. Methods: Our study involved a large cohort of 73,511 individuals aged 30–79 from China’s multi-ethnic population. We employed satellite observations and the chemical transport model (GEOS-Chem)to estimate the long-term exposure to PM 2.5 and its components. Anemia was defined, according to WHO guidelines, as Hb levels below 130 g/L for men and below 120 g/L for women. Through logistic regression, we investigated the association between PM 2.5 components and anemia. By utilizing weighted quantile sum (WQS) analysis, we identified key components and gained insights into their combined impact on anemia. Overall, our study sheds light on the relationship between PM 2.5 exposure, its constituents, and the risk of anemia in a large cohort. Results: PM 2.5 and three components, nitrate (NIT), organic matter (OM), and soil particles (SOIL), were associated with anemia. Per-standard deviation increase in the 3-year average concentrations of PM 2.5 [odds ratio (OR): 1.14, 95% confidence interval (CI): 1.01, 1.28], NIT (1.20, 1.06, 1.35), OM (1.17, 1.04, 1.32), and SOIL (1.22, 1.11, 1.33) were associated with higher odds of anemia. In WQS regression analysis, the WQS index was associated with anemia (OR: 1.29, 95% CI: 1.13, 1.47). SOIL has the highest weight among all PM 2.5 components. Conclusions: Long-term exposure to PM 2.5 and its constituents is associated with anemia. Moreover, SOIL might be the most critical component of the relationship between PM 2.5 and anemia. Our research increases the evidence of the association between PM 2.5 and anemia in the general population, and targeted emission control measures should be taken into consideration to mitigate the adverse effects of PM 2.5 -related anemia.