PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype

Fengsheng Dai; Yixiao Yuan; Jiaqi Hao; Xing Cheng; Xiangyi Zhou; Li Zhou; Rui Tian; Yi Zhao; Tingxiu Xiang

Genes and Diseases (Sep 2024)

PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype

Fengsheng Dai,
Yixiao Yuan,
Jiaqi Hao,
Xing Cheng,
Xiangyi Zhou,
Li Zhou,
Rui Tian,
Yi Zhao,
Tingxiu Xiang

Affiliations

Fengsheng Dai: Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China
Yixiao Yuan: Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
Jiaqi Hao: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
Xing Cheng: Department of Neuro-Oncology, Chongqing University Cancer Hospital, Chongqing 400030, China
Xiangyi Zhou: Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
Li Zhou: Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China
Rui Tian: Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China
Yi Zhao: Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China
Tingxiu Xiang: Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China; Corresponding author. Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

Journal volume & issue: Vol. 11, no. 5
p. 101106

Abstract

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Programmed cell death 2 (PDCD2) is related to cancer progression and chemotherapy sensitivity. The role of PDCD2 in solid cancers (excluding hematopoietic malignancies) and their diagnosis and prognosis remains unclear. The TCGA, CGGA, GEPIA, cBioPortal, and GTEx databases were analyzed for expression, prognostic value, and genetic modifications of PDCD2 in cancer patients. Functional enrichment analysis, CCK8, colony formation assay, transwell assay, and xenograft tumor model were undertaken to study the PDCD2's biological function in glioma (GBMLGG). The PDCD2 gene was associated with solid cancer progression. In the functional enrichment analysis results, PDCD2 was shown to participate in several important GBMLGG biological processes. GBMLGG cells may be inhibited in their proliferation, migration, invasion, and xenograft tumor growth by knocking down PDCD2. Our research can provide new insights into solid cancer prognostic biomarkers of PDCD2.

Published in Genes and Diseases

ISSN: 2352-3042 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Medicine: Medicine (General); Science: Biology (General): Genetics
Website: https://www.keaipublishing.com/en/journals/genes-and-diseases/

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