Italian Journal of Animal Science (Jan 2010)

The FAGenomicH project: towards a whole candidate gene approach to identify markers associated with fatness and production traits in pigs and investigate the pig as a model for human obesity

  • Vincenzo Russo,
  • Rita Casadio,
  • Giovanni Romeo,
  • Manuela Vargiolu,
  • Elena Bonora,
  • Daniela Giovanna Calò,
  • Giuliano Galimberti,
  • Lucia Tognazzi,
  • Camilla Speroni,
  • Emilio Scotti,
  • Michela Colombo,
  • Raffaele Fronza,
  • Luca Fontanesi

DOI
https://doi.org/10.4081/ijas.2009.s2.87
Journal volume & issue
Vol. 8, no. 2s
pp. 87 – 89

Abstract

Read online

Fatness in pigs is a complex trait for which a large number of genes are expected to be involved. Genetics of human obesity could take advantages from genetic information coming from the pig and vice versa. To these aims, a comprehensive candidate gene approach could be helpful. We catalogued all genes affecting fatness on both species, and identified in silico and by resequencing porcine SNPs on a large number of candidate genes. In addition, we applied a selective genotyping approach to identify markers associated with fat deposition in pigs. This approach was tested genotyping the IGF2 intron3-g.3072G>A mutation and novel markers in the PCSK1 and TBC1D1 genes. Polymorphisms in these genes resulted associated with back fat thickness in Italian Large White pigs.

Keywords