PLoS ONE (Jan 2021)

Association between serum 25-hydroxyvitamin D and physical performance measures in middle-aged and old Japanese men and women: The Unzen study.

  • Michiko Uchiyama,
  • Satoshi Mizukami,
  • Kazuhiko Arima,
  • Takayuki Nishimura,
  • Yoshihito Tomita,
  • Yasuyo Abe,
  • Natsumi Tanaka,
  • Yuzo Honda,
  • Hisashi Goto,
  • Maiko Hasegawa,
  • Youko Sou,
  • Ritsu Tsujimoto,
  • Mitsuo Kanagae,
  • Makoto Osaki,
  • Kiyoshi Aoyagi

DOI
https://doi.org/10.1371/journal.pone.0261639
Journal volume & issue
Vol. 16, no. 12
p. e0261639

Abstract

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PurposeRegarding epidemiological studies, the role of vitamin D in musculoskeletal functionality (muscle weakness and physical performance) among elderly people is still controversial. The purpose of the present study was to investigate the associations between 25-hydroxyvitamin D [25(OH)D] and physical performance among community-dwelling middle-aged and old Japanese men and women.MethodsThe subjects were community-dwelling 297 men and 415 women aged 50 years and over. Data on height (m) and weight (kg) were collected. Serum 25(OH)D, parathyroid hormone, calcium, and albumin levels were measured. Serum 25(OH)D was classified into deficiency group: ResultsVitamin D deficiency and insufficiency based on serum 25(OH)D levels were observed in 15.2% and 56.9% of men and 52.0% and 43.6% of women, respectively. In men, higher serum 25(OH)D levels were associated with better grip strength (p for trend = 0.003), chair stand time (p for trend = 0.042), and functional reach (p for trend ConclusionA higher level of serum 25(OH)D was associated with better physical performance in men but not in women.