Prenatal management of fetal goiter alternating between hypothyroidism and hyperthyroidism in a mother with Graves’ disease

Abstract

Abstract We present a rare documented case with consecutive hypo‐ and hyperthyroidism during fetal life. First, hypothyroidism was due to transplacental passage of antithyroid drugs. After the mother's thyroidectomy, fetal hyperthyroidism was due to transplacental passage of persistent anti‐thyrotropin receptor antibodies. Fetal goiter disappeared after adjusting maternal treatment.

Keywords

• endocrinology and metabolic disorders
• fetal goiter
• maternal Grave's disease
• obstetrics and gynecology
• prenatal management