Nature Communications (Jun 2019)
Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness
- Meaghan Boileau,
- Margret Shirinian,
- Tenzin Gayden,
- Ashot S. Harutyunyan,
- Carol C. L. Chen,
- Leonie G. Mikael,
- Heather M. Duncan,
- Andrea L. Neumann,
- Patricia Arreba-Tutusaus,
- Nicolas De Jay,
- Michele Zeinieh,
- Katya Rossokhata,
- Yelu Zhang,
- Hamid Nikbakht,
- Carine Mouawad,
- Radwan Massoud,
- Felice Frey,
- Rihab Nasr,
- Jean El Cheikh,
- Marwan El Sabban,
- Claudia L. Kleinman,
- Rami Mahfouz,
- Mark D. Minden,
- Nada Jabado,
- Ali Bazarbachi,
- Kolja Eppert
Affiliations
- Meaghan Boileau
- Division of Experimental Medicine, McGill University and McGill University Heath Centre Research Institute
- Margret Shirinian
- Department of Experimental Pathology, Immunology, and Microbiology, American University of Beirut
- Tenzin Gayden
- Department of Human Genetics, McGill University
- Ashot S. Harutyunyan
- Department of Human Genetics, McGill University
- Carol C. L. Chen
- Department of Human Genetics, McGill University
- Leonie G. Mikael
- Department of Pediatrics, McGill University and McGill University Heath Centre Research Institute
- Heather M. Duncan
- Division of Experimental Medicine, McGill University and McGill University Heath Centre Research Institute
- Andrea L. Neumann
- Research Institute of the McGill University Health Centre and McGill University
- Patricia Arreba-Tutusaus
- Research Institute of the McGill University Health Centre and McGill University
- Nicolas De Jay
- Department of Human Genetics, McGill University
- Michele Zeinieh
- Department of Human Genetics, McGill University
- Katya Rossokhata
- Department of Human Genetics, McGill University
- Yelu Zhang
- Research Institute of the McGill University Health Centre and McGill University
- Hamid Nikbakht
- Department of Human Genetics, McGill University
- Carine Mouawad
- Department of Experimental Pathology, Immunology, and Microbiology, American University of Beirut
- Radwan Massoud
- Department of Internal Medicine, American University of Beirut
- Felice Frey
- Department of Experimental Pathology, Immunology, and Microbiology, American University of Beirut
- Rihab Nasr
- Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut
- Jean El Cheikh
- Department of Internal Medicine, American University of Beirut
- Marwan El Sabban
- Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut
- Claudia L. Kleinman
- Department of Human Genetics, McGill University
- Rami Mahfouz
- Department of Pathology and Laboratory Medicine, American University of Beirut
- Mark D. Minden
- Princess Margaret Cancer Centre, University Health Network, University of Toronto
- Nada Jabado
- Department of Human Genetics, McGill University
- Ali Bazarbachi
- Department of Internal Medicine, American University of Beirut
- Kolja Eppert
- Department of Pediatrics, McGill University and McGill University Heath Centre Research Institute
- DOI
- https://doi.org/10.1038/s41467-019-10705-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
The role of histone mutations in leukemogenesis remains largely unexplored. In this study of AML, the authors show that histone mutations are early events that drive a more aggressive phenotype.
