Measurements of heterogeneity in proteomics analysis of the nanoparticle protein corona across core facilities

Ali Akbar Ashkarran; Hassan Gharibi; Elizabeth Voke; Markita P. Landry; Amir Ata Saei; Morteza Mahmoudi

doi:10.1038/s41467-022-34438-8

Nature Communications (Nov 2022)

Measurements of heterogeneity in proteomics analysis of the nanoparticle protein corona across core facilities

Ali Akbar Ashkarran,
Hassan Gharibi,
Elizabeth Voke,
Markita P. Landry,
Amir Ata Saei,
Morteza Mahmoudi

Affiliations

Ali Akbar Ashkarran: Department of Radiology and Precision Health Program, Michigan State University
Hassan Gharibi: Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Elizabeth Voke: Department of Chemical and Biomolecular Engineering, University of California, Berkeley
Markita P. Landry: Department of Chemical and Biomolecular Engineering, University of California, Berkeley
Amir Ata Saei: Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
Morteza Mahmoudi: Department of Radiology and Precision Health Program, Michigan State University

DOI: https://doi.org/10.1038/s41467-022-34438-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Analysis of the protein corona formed around nanoparticles is important for multiple applications in nanomedicine, the methods used at core facilities used for analysis can impact the results. Here, the authors report on a study into the variability of the results obtained from 17 different core facilities and the implications of this.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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