Communications Biology (Apr 2022)
Silencing of STE20-type kinase STK25 in human aortic endothelial and smooth muscle cells is atheroprotective
- Emmelie Cansby,
- Sima Kumari,
- Mara Caputo,
- Ying Xia,
- Rando Porosk,
- Jonathan Robinson,
- Hao Wang,
- Britt-Marie Olsson,
- Josefine Vallin,
- Julie Grantham,
- Ursel Soomets,
- L. Thomas Svensson,
- Carina Sihlbom,
- Hanns-Ulrich Marschall,
- Andreas Edsfeldt,
- Isabel Goncalves,
- Margit Mahlapuu
Affiliations
- Emmelie Cansby
- Department of Chemistry and Molecular Biology, University of Gothenburg and Sahlgrenska University Hospital
- Sima Kumari
- Department of Chemistry and Molecular Biology, University of Gothenburg and Sahlgrenska University Hospital
- Mara Caputo
- Department of Chemistry and Molecular Biology, University of Gothenburg and Sahlgrenska University Hospital
- Ying Xia
- Department of Chemistry and Molecular Biology, University of Gothenburg and Sahlgrenska University Hospital
- Rando Porosk
- Department of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu
- Jonathan Robinson
- Department of Biology and Biological Engineering, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology
- Hao Wang
- Department of Biology and Biological Engineering, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology
- Britt-Marie Olsson
- Proteomics Core Facility, University of Gothenburg
- Josefine Vallin
- Department of Chemistry and Molecular Biology, University of Gothenburg and Sahlgrenska University Hospital
- Julie Grantham
- Department of Chemistry and Molecular Biology, University of Gothenburg and Sahlgrenska University Hospital
- Ursel Soomets
- Department of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu
- L. Thomas Svensson
- Department of Biology and Biological Engineering, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology
- Carina Sihlbom
- Proteomics Core Facility, University of Gothenburg
- Hanns-Ulrich Marschall
- Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital
- Andreas Edsfeldt
- Department of Clinical Sciences Malmö, Clinical Research Center, Lund University
- Isabel Goncalves
- Department of Clinical Sciences Malmö, Clinical Research Center, Lund University
- Margit Mahlapuu
- Department of Chemistry and Molecular Biology, University of Gothenburg and Sahlgrenska University Hospital
- DOI
- https://doi.org/10.1038/s42003-022-03309-9
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 14
Abstract
Silencing of STK25, an STE20-type kinase, in human aortic endothelial and smooth muscle cells reduces lipid accumulation and suppresses inflammation and fibrotic pathways, ultimately exerting atheroprotective effects.
